Your email address will not be published. We are licensed by CLIA, the federal agency regulating laboratories, as well as by those states requiring individual licenses in addition to CLIA. In PKU, there is a defect in the gene for phenylalanine hydroxylase (PAH), which is responsible for converting the amino acid phenylalanine to tyrosine (5). For cars, the exhaust fumes that come out of the tailpipe are a byproduct of fuel combustion, and the composition can tell us how efficiently the engine burns fuel. … These disorders include, but are not limited to: hyperactivity, movement disorders, and immune function. News & Updates See All › Provider Spotlight: Jenny Abercrombie, ND. Abnormally high levels of these microorganisms can cause or worsen behavior disorders, hyperactivity, … This site uses Akismet to reduce spam. I love when I can identify a biochemical glitch and someone can have such a profound emotional turn around. Organic acid testing (OAT) has become very popular amongst functional medicine doctors and dietitians. Chronic inflammation can push the metabolism of tryptophan down the kynurenine pathway,  increasing levels of certain organic acids in the nervous system and urine, including (127): These organic acids can bind to NMDA receptors within the nervous system and increase (quinolinate and picolinate) or decrease (kynurenate) their excitatory activity. Organic Acids Test – clinically significant areas Yeast & Bacteria. The accumulation of an organic acid in cells and fluids (plasma, cerebrospinal fluid, or urine) leads to a disease called organic acidemia or organic aciduria. The resulting organic acids are used by the body to generate cellular energy and provide many of the building blocks necessary for cell function. Urinary organic acid measurement offers a functional assessment of nutrient status. The cause of these high levels could include oral antibiotic use, high sugar diets, immune deficiencies, acquired infections, as well as genetic factors.Our Organic Acids Test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels, and is the only OAT to include markers for oxalates, which are highly correlated with many chronic illnesses.If abnormalities are detected using the OAT, treatments can include supplements, such as vitamins and antioxidants, or dietary modification. The Organic Acids Test (OAT) provides an accurate evaluation of intestinal yeast and bacteria. The most common chemical groups associated with organic acids are carboxylic acids which are present in the conjugate base form at neutral pH, 7.0, the pH of the inside of most living cells. However, they also offer Organix Dysbiosis, which is a separate test for just for microbial OAs (similar to MOAT from Great Plains). Urinary organic acids typically tested that involve the mitochondria include: When these organic acids are out of balance, this clues the clinician to search for factors that may be impairing mitochondrial function. We use the following tests: Amino Acids - Urine Test. Erica, I have done the OAT and all the, now typical, functional: blood and fecal tests. The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with over 70 markers. The main reasons for abnormal urinary organic acid results include: We’ll review each of these scenarios in detail below. One of the most important uses of the organic acids test is as an indicator of dysbiosis, an abnormal overgrowth of yeast and bacteria in the intestinal tract. Based in Asheville and Atlanta, we provide testing services to all 50 states and around the world. Your healthcare practitioner can order it for you, but it is not always covered by insurance. Organic acid testing is still mostly used for the diagnosis of these disorders, but the science has progressed, and now we can use OAT to evaluate overall metabolic health as well. These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. This urine-based test provides a wealth of information about the functioning of various bodily systems and can be used to identify possible nutrient deficiencies, gut dysbiosis, and more. Antioxidant levels that are indirectly measured via urinary organic acid testing (along with their corresponding organic acids) include: It is also possible to indirectly measure DNA damage caused by high levels of oxidative stress via the following urinary marker: Some substances that our bodies absorb within the gut are shuttled to our liver, where they are transformed into water-soluble molecules that can be excreted in the sweat, urine, or bile. I have had a great deal of success in treating complicated PMS cases that didn't respond to typical female hormone balancing therapies. It also evaluates oxalate toxicity, as well as mitochondria function, and various […] The Great Plains Laboratory, Inc.11813 West 77th StreetLenexa, KS 66214, The Great Plains Laboratory, Inc., 11813 West 77th Street, Lenexa, KS, 66214, United States, GPL-TOX Profile (Toxic Non-Metal Chemicals). However, about 50% of these disorders are not detected until later in childhood, and some aren’t diagnosed until adulthood (16). In some ways, interpreting OAT results is a lot like working on a puzzle – you can’t fully understand what you’re seeing until you’ve put all the pieces together. This is why organic acids are rarely tested in blood or serum. These small, discarded organic acid molecules are byproducts of human cellular activity, the digestion of foods, and the metabolism of gastrointestinal flora. ... metabolite in urine samples of male infants, control boys, and boys with autism Control infants Control boys 2-13 years Autistic Boys 2-13 years 46. Erica and Amy are experienced registered dietitians who are passionate about creating great nutrition content! Patient should avoid apples, grapes (including raisins), pears, cranberries and their juices 48 hours prior to specimen collection. Listen to The Lab Report podca… There are over 70 markers on the organic acids test including vitamins and antioxidants, oxidative stress, energy production, detoxification, neurotransmitter levels, oxalates, and intestinal yeast and bacteria. Omega-3 Index Complete Test. It is definitely a labor of love . Organic Acids Test (OAT) - Urine Test More research is needed to understand the health implications of elevated levels of these organic acids, but it can indicate a possible issue with inflammation. These missing or malfunctioning enzymes prevent important biochemical reactions from occurring and cause metabolites (including organic acids) to accumulate (1). , currently includes in-depth notes on interpreting the neurotransmitter-related organic acids, and additional notes will be added in the future. Some of these bacterial byproducts from the intestine enter the blood stream and may alter the metabolism of neurotransmitters such as dopamine. It gives clues if we have a blockage, nutritional insufficiencies, and/or bacterial overgrowth. Oxidative stress occurs when there is an imbalance between free radicals and antioxidants within the body (89). Is this test right for you? Reason #4: Impaired Fatty Acid Metabolism, Reason #5: Ketosis or Poor Carbohydrate Metabolism. HPHPA (3-(3-hydroxyphenyl)-3-hydroxypropionic acid) An abnormal phenylalanine metabolite produced by gastrointestinal bacteria of . Price varies for international OAT kits – please contact our laboratory for more information on international kits. Types of dysbiosis (and their associated urinary organic acids typically measured) include: Elevated levels of the “general bacterial overgrowth” organic acids are not diagnostic of any particular overgrowth but can help guide further testing decisions. that can be used as a follow-up to the OAT for patients who have been treated for dysbiosis. It can also be used to identify subclinical (non-symptomatic) metabolic imbalances in order to PREVENT chronic illness from developing. Test Overview of Organic Acid Test Panel (OAT) The Organic Acid Test Panel examines metabolites found in a patient's urine that are products of body metabolism and of gut microbes. Since utilizing the OAT, it has provided me with a variety of information to determine the underlying cause of female related issues. When PAH isn’t working properly, the body tries to metabolize phenylalanine through an alternative pathway, and organic acids like phenyllactate and phenylacetate are produced as a result (6, 7). Thus, organic acids in urine are often present at 100 times their concentration in the blood serum and thus are more readily detected in urine. For more information on the Comprehensive OAT, look here. They also offer a Microbial Organic Acids Test (MOAT) that can be used as a follow-up to the OAT for patients who have been treated for dysbiosis. About the Organic Acid Test (OAT) The Organic Acid Test is a comprehensive assessment for a wide variety of biomarkers related to yeast (candida) and bacteria toxicity – specifically clostridia bacteria. In others, such as medium chain acyl dehydrogenase deficiency, a child might appear completely normal until a potentially fatal episode of cardiorespiratory arrest. Great Plains Urine Organic Acid Test: The Organic Acids Test (OAT) Provides A Metabolic Snapshot based on the products the body discards through the urine. The Organic Acids Test (OAT) provides an accurate evaluation of intestinal yeast and bacteria. Organic acids are chemical compounds excreted in the urine of mammals that are products of metabolism. offers a more detailed evaluation, with over 40 OAs. Report Tour. Many organic acidemias are associated with slight to marked increases in plasma ammonia. This video gives an overview of what we should see on the DUTCH Complete™ report. Inborn errors of metabolism are another common cause (39, 40, 41). AD(H)D Panel. Organic Acids Test is one of my favorite tests because of the amount of information it gives and the fact that it is a non-invasive urine test which can be done at home. Some of the markers that I find valuable for women's health issues are the bacterial and yeast metabolites, oxalates, B vitamins, vitamin C, and pyroglutamic acid. An organic acid is any compound that generates protons at the prevailing pH of human blood. … Organic acids with one carboxylic acid have one conjugate base while some organic acids may have two or three carboxylic acids and two or three conjugate bases. Additionally, MMA and formiminoglutamate levels can provide insight into how well methylation pathways are functioning within the body since B12 and folate are important methyl donors. Urine. 2. A number of organic acids directly or indirectly indicate deficiencies of critical vitamins such as vitamin B12, pantothenic acid, biotin, and others. GPL-TOX - Toxic Organic Chemical Profile - Urine Test. In humans, organic acids are byproducts or intermediates of chemical reactions that occur within the body (1). Some organic acidemias may be chronic and present in the first few days of life. In short, I don’t recommend this as your first go-to test for gut health—or any health—diagnosis. I’d be lying if I said it wasn’t one of my favourite tests to interpret. Click here to get a PDF copy delivered to your inbox. It provides an evaluation of intestinal yeast and bacteria. (, Chronic inflammation can push the metabolism of tryptophan down the kynurenine pathway,  increasing levels of certain organic acids in the nervous system and urine, including (, The sample is then frozen and shipped to the laboratory, where organic acids are measured from the urine sample using liquid or gas chromatography-mass spectrometry (, Chromatography separates all of the different components found in the urine sample, while mass spectrometry is a tool used to identify and quantify each component by looking at its chemical makeup (, While it might be tempting to focus on individual OAs that show abnormal results, the overall pattern of abnormalities is more important (. Your practitioner will receive a report that lists the levels of individual organic acids as either being high, low, or within the normal range. The Organic Acids Test (OAT) is a comprehensive test that gives metabolic insight into a person’s overall health. OAT is not able to detect intestinal parasites that might be contributing to your symptoms. For example, one of the better known inborn errors of metabolism is phenylketonuria (PKU). As a result, organic acids begin to build up and are excreted in the urine: Our urinary organic acid profiles can give us clues as to what’s happening in our bodies, and this is the basis of organic acid testing. Many genetic disorders are caused by the production of an inefficient enzyme that reacts at a slower than usual rate, resulting in an accumulation of a metabolic intermediate. 1. Organic acids that can indicate possible vitamin B deficiencies when out of range include: However, many of these markers have other factors that can increase or decrease their levels, so proper test prep and interpretation is important. I haven’t heard of this testing before so I really appreciate the thorough insight! species, including. However, in all of these cases, blood tests are more reliable and your doctor is likely to order them for confirmation. Over 1,000 different organic acids have been detected in urine since this kind of testing started. The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with 76 markers. These disorders are rare, but their effects can be devastating (4). I need to find someone who take medicare to evaluate my results. Unusually high levels of these microorganisms often cause or increase the severity of behavior disorders. Biometrix Labs Urine Organic Acid Testing About Organic Acids Organic Acids are chemical compounds which are used in essential metabolic processes of the body, these metabolic processes govern how your body changes food into the energy the body needs to … You can find a schedule of their upcoming training here. OAT is relatively expensive and often isn’t covered by insurance, so it’s not a reasonable option for everyone. Organic acid testing (OAT) is often compared to performing an emissions test on a car. I cannot imagine the amount of research that went into this article (and your whole blog, for that matter!). It also evaluates oxalate toxicity, as well as mitochondria function, and various markers for … Urinary organic acids related to detoxification and/or liver and kidney function that are commonly measured on OATs include (101): Depending on which organic acid levels are out of range, nutrition and lifestyle interventions may be recommended, including: A practitioner well-versed in functional nutrition can best assist in these recommendations. When the body isn’t functioning optimally, organic acids in the urine can become elevated or depleted, depending on what is occurring. In humans, organic acids are byproducts or intermediates of chemical reactions that occur within the body (, Some factors that can influence organic acid production within the body include (, Inborn errors of metabolism are genetic disorders that disrupt biochemical pathways in the body (, These disorders are rare, but their effects can be devastating (, Often, there is a defect in a gene that codes for a certain enzyme, causing the body to either produce malfunctioning enzymes or none of the enzymes at all, These missing or malfunctioning enzymes prevent important biochemical reactions from occurring and cause metabolites (including organic acids) to accumulate (, In PKU, there is a defect in the gene for phenylalanine hydroxylase (PAH), which is responsible for converting the amino acid phenylalanine to tyrosine (, When PAH isn’t working properly, the body tries to metabolize phenylalanine through an alternative pathway, and organic acids like phenyllactate and phenylacetate are produced as a result (, In the United States, all newborns are screened for these diseases, so they’re usually diagnosed quickly (, However, about 50% of these disorders are not detected until later in childhood, and some aren’t diagnosed until adulthood (, For example, elevated levels of the organic acid methylmalonic acid (MMA) in the urine are a well-validated indicator of vitamin B12 deficiency (, Alpha-ketoisovalerate, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate (, benzoate, hippurate, indican, phenylacetate, phenylpropionate, p-cresol, p-hydroxybenzoate, p-hydroxyphenylacetate, and tricarballylate (, Elevated levels of the “general bacterial overgrowth” organic acids are. Organic acids are organic compounds that are acidic. If there is a deficiency or dysfunction in a metabolic pathway, there will be an accumulation of an organic acid, that spills into the urine. Learn More. If you have additional questions regarding our licenses or quality assurance practices, please contact us. It helps provide a bigger picture of mitochondrial function, nutrient deficiencies, neurotransmitter metabolism, antioxidant status, detoxification abilities, and gut health, which trained and experienced clinicians can use to dig deeper. The number of organic acids found in urine is enormous. Although some organic acidemias result in lowered blood pH, other organic acidemias are associated with organic acids that are relatively weak and do not typically cause acidosis. Click here to learn more about the how's and why's of testing your hormones. Thank you so much Sarah! These ketones can be detected in the urine with organic acid testing: Even when not in ketosis, high levels of other urinary organic acids can identify possible issues with carbohydrate metabolism. While it might be tempting to focus on individual OAs that show abnormal results, the overall pattern of abnormalities is more important (133). Organic Acid Test URINE SAMPLE. We use the following tests: Glyphosate - Urine Test. Inborn errors of metabolism are another common cause (, When you fast or consume a very low-carbohydrate diet, the body naturally produces ketones to be used for energy instead, These ketones can be detected in the urine with organic acid testing, Elevated levels can be due to genetic mutations or deficiencies in required nutrients like thiamin, lipoic acid, CoQ10, pantothenic acid, riboflavin, or niacin (, Urinary levels of these organic acids can be impacted by things like genetic snps, nutrient deficiencies, diet, exposure to environmental toxins, stress, sleep, neuroendocrine tumors, supplements, and adrenal function (, Mitochondrial dysfunction (when mitochondria do not produce energy at their optimal rate) can be caused by genetic disorders, inadequate nutrition, inflammation, environmental toxins, medications, viral infections, and DNA damage (, More recently, scientists have learned that less severe mitochondrial dysfunction plays a role in many chronic conditions, including cancer, diabetes, epilepsy, and neurodegenerative diseases like Parkinson’s, Alzheimer’s, and Huntington’s disease (, Organic acid testing is one of the best ways to test for mitochondrial dysfunction, since it measures most of the intermediates in the citric acid cycle (, Nutritional factors include deficiency in coenzyme Q10, carnitine, riboflavin, thiamin, niacin, vitamin B12, iron, magnesium, or manganese, all of which are required for cellular respiration (energy production) in the mitochondria (, Oxidative stress occurs when there is an imbalance between free radicals and antioxidants within the body (, Free radicals are unstable atoms that steal electrons from other molecules, leading to cellular damage (, High levels of free radicals and oxidative stress contribute to chronic diseases like cancer and heart disease (, Thankfully, our bodies can use antioxidants to destroy free radicals and counteract oxidative stress (, pyroglutamic acid and 2-hydroxybutyric acid (, Urinary organic acids related to detoxification and/or liver and kidney function that are commonly measured on OATs include (, Reducing exposure to environmental toxins, Correcting nutrient deficiencies that may impair these pathways (glycine, glutamine, taurine, cysteine, methionine, pantothenic acid, riboflavin, niacin, vitamin B6, folate, vitamin B12)  (, Adding foods or supplements to the diet that enhance the body’s natural detoxification abilities (magnesium, NAC, zinc, selenium, copper, manganese, antioxidants, thiols, etc.) This as your first go-to Test for gut health—or any health—diagnosis Great deal of success in treating complicated PMS that. 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